You can install our 3/8" Sport-Loc Rubber Tiles in a garage, but we wouldn't recommend it. Since these are tiles, there is potential for the tiles to come apart during certain moves when driving into your garage. If you just pull in and out of your garage, installing these tiles would work just fine, but if you turned the wheel for any reason, then the tiles would have the potential to come apart. Parking a car over the tiles will not damage the tiles in any way. The only issue that you may run into is that if your car were to leak oil, that over time the tiles may break down. To prevent this, we recommend installing our Nitro Rolls or one of Auto Floor Guards mats under your car.